Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking
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چکیده
منابع مشابه
Lipids as targeting signals: lipid rafts and intracellular trafficking.
Our view of biological membranes has evolved dramatically over the last few decades. In the bilayer model from Singer & Nicholson (Science 1972;175:720-731), both proteins and lipids freely diffuse within the plane of the membrane. Currently, however, membranes are viewed as a mosaic of different compartments or domains maintained by an active cytoskeleton network (Ritchie et al. Mol Membr Biol...
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Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are oft...
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Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally segregate its constituents. This capability is based on dynamic liquid-liquid immiscibility and underlies the raft concept of membrane subcompartmentalization. Lipid rafts are fluctuating nanoscale assemblies of s...
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ژورنال
عنوان ژورنال: Traffic
سال: 2004
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2004.0181.x